Substrate: Cyclin D1 (Cyclin D1)
Seq-ID: P24385 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-50433   CDK4_HUMAN
MINT-50434   CDK6_HUMAN
MINT-50435   MCM10_HUMAN
MINT-50437   CDN1A_HUMAN
MINT-7033534   CDK4_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding cytosol,
cyclin-dependent protein kinase holoenzyme complex,
nucleoplasm		 positive regulation of protein amino acid phosphorylation,
cell division,
response to UV-A,
mitotic cell cycle G1/S DNA damage checkpoint,
G1/S transition of mitotic cell cycle,
response to drug,
positive regulation of cyclin-dependent protein kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 90 LAMNYLDRFLSLEPVKKSRLQ PKA_group 8058338
LTP
1.00
 - CYCLIN
0.08
 2W96 14.75%
S 197 ALCATDVKFISNPPSMVAAGS PKA_group 8058338
LTP
0.06
 - Cyclin_C
0.16
 2W96 57.38%
S 234 LSYYRLTRFLSRVIKCDPDCL PKA_group 8058338
LTP
0.15
 - Cyclin_C
0.05
 2W96 4.10%
T 286 EEEEEVDLACTPTDVRDVDI  GSK-3_group 9832503
LTP
0.98
 - -
0.49
 --
T 286 EEEEEVDLACTPTDVRDVDI  IKK_alpha 16103118
LTP
0.98
 - -
0.49
 --
T 286 EEEEEVDLACTPTDVRDVDI  GSK-3_group 10766840
LTP
0.98
 - -
0.49
 --

Substrate: Cyclin D1 (Cyclin D1)
Seq-ID: P25322 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-7033488   CDK4_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase regulator activity,
protein kinase binding,
protein kinase activity		 cytosol,
cyclin-dependent protein kinase holoenzyme complex,
nucleoplasm		 protein amino acid phosphorylation,
fat cell differentiation,
cell division,
mitotic cell cycle G1/S DNA damage checkpoint,
mammary gland epithelial cell proliferation,
G1/S transition of mitotic cell cycle,
negative regulation of epithelial cell differentiation,
negative regulation of Wnt receptor signaling pathway,
canonical Wnt receptor signaling pathway,
lactation,
re-entry into mitotic cell cycle,
endoplasmic reticulum unfolded protein response,
mammary gland alveolus development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 286 EVEEEAGLACTPTDVRDVDI  GSK-3_beta 15075324
LTP
1.00
 - Cyclin_C
0.44
 - medium
T 286 EVEEEAGLACTPTDVRDVDI  GSK-3_beta 11124803
LTP
1.00
 - Cyclin_C
0.44
 - medium
T 288 EEEAGLACTPTDVRDVDI    DYRK1B 15075324
LTP
1.00
 - -
0.39
 - medium

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